Brian Beck

Brian Beck

Life Science Research Associate

Life Sciences Computing Group

Dallas/Fort Worth, TX

Brian uses structural bioinformatics approaches to explore spatial and energetic patterns in protein:protein interactions. He joined the Life Sciences Group at TACC in the Spring of 2015 after developing the Nevada Center for Bioinformatics and later working as a Computational Biology professor at Texas Woman's University. He is based out of the UT Southwestern Medical Center in Dallas with the goal of supporting computational biology and bioinformatics research in DFW metroplex UT institutions.Brian works in multiple locations in the Dallas/Fort Worth metroplex. To see his current location, click here.


  • BS: Biochemistry & Biophysics: 1991 from Texas A&M University, College Station: Enzymology and bioinformatics of metabolic proteins : with Dr. Don Pettigrew
  • PhD: Biochemistry & Biophysics: 1997 from Washington State University, Pullman, WA: Molecular dynamics studies of how metalloproteins control their redox potentials during electron transfer reactions : with Dr. Toshiko Ichiye
  • Post Doc: Chemistry and Institute for Molecular Design: 1998-2004 at University of Houston: Molecular dynamics studies of solvation of protein/protein and protein/DNA interfaces: with Dr. B. Montgomery Pettitt

Organization Membership/Professional Affiliations

  • International Society of Computational Biology (ISCB)
  • Protein Society
  • Biophysical Society
  • AAAS
  • American Chemical Society (ACS)
  • Texas Society for Microscopy (TSM)

Selected Publications

Reddy JM, McConnell JA, Samuel F, Reddy CP, Contreras J, Beck BW, Hynds, DL (2014) Non-Prenylatable, Cytosolic Rac1 Alters Neurite Outgrowth While Retaining Guanosine Triphosphate (GTP) Loading. Cellular Signaling. 12/2014; DOI: 10.1016/j.cellsig.2014.11.033. Epub available before publication.

Sudarshan, S, Kodathala, S, Mahadik, AC, Mehta, I, and Beck, BW (2014) Protein-Protein Interface Detection Using the Energy Centrality Relationship (ECR) characteristic of proteins. PLoS One. May 15, 2014. DOI: 10.1371/journal.pone.0097115

Alexandra Wright, Amruta C. Mahadik, S. Haldar, D. L. Hynds, Brian W. Beck (2013) Mutation Of Arp3 Serine 226 Alters Protein Conformation. Texas Journal of Microscopy, 2013, 44 (1): 15.

Mahadik, A., Beck, B.W. (2011) Identification of interfacial residues of Arp3 important to the Arp2/3 Complex activation of branched actin filaments. Texas Journal of Microscopy, 2011, 42 (1): 6.

Mahadik Amruta C., Haldar Sounick, Hynds D. L., Beck, Brian W. (2011) Computationally Predicting The Role of Arp3 Residues In The Nucleation Event At Pointed End Of Arp2/3 Complex During Branching Of Actin Filaments. Texas Journal of Microscopy, 2011, 42 (1): 6.

Chen, C., Beck, B.W., Krause, K., Warth, T., and Pettitt, B.M. (2007) The Effects of Dimerization of Serratia marcescens Endonuclease on Water Dynamics. Biopolymers 85(3):241-252.

Salzameda, B., Facemyer, K.C., Beck, B.W., and Cremo, C.R. (2006) The N-terminal Lobes of Both Regulatory Light Chains Interact with the Tail Domain of Smooth Muscle Myosin in the 10S Conformation. Journal of Biological Chemistry. 281(50):38801-11.

Lyle, N.J., Williams, I., Brar, K.R, Beck, B. W., and Dascalu, S. M. (2005) Specification of AutomN: An Automatic Protein Sequence to Protein-Protein Interaction Software System. Proceedings of the 2005 International Conference on Software Engineering Research and Practice (SERP'05) June 27-30, 2005 Las Vegas, NV, USA.

Chen, C, Beck, B. W., Krause,K., and Pettitt, B. M. (2004) Solvent participation in Serratia marcescens endonuclease complexes with DNA. Proteins: Structure, Function, and Bioinformatics 62(4):982-995.

Dolan, E., Yelle, R., Beck, B., Fischer, J, and Ichiye, T. (2004) Protein Control of Electron Transfer Rates via Polarization: Molecular Dynamics Studies of Rubredoxin. Biophys J. 86(4):2030-2036.

Beck, B. W., Xie, Q., and T. Ichiye. (2001). Sequence Determination of Reduction Potentials by Cysteinyl Hydrogen Bond and Peptide Dipoles in [4Fe-4S] Ferredoxins. Biophys. J. 81:601-613.`

Beck, B. W., J. B. Koerner, and T. Ichiye. (1999). Metal substitution in analogs of rubredoxin: Implications for redox potential control. J. Phys. Chem.B 103:8006-8015.

Swartz, P. D., B. W. Beck, and T. Ichiye. (1996). Structural origins of redox potentials in Fe-S proteins: Electrostatic potentials of crystal structures. Biophys. J. 71:2958-2969.

Yang, Y., B. W. Beck, V. S. Shenoy, and T. Ichiye. (1993). Aqueous solvation of a rubredoxin redox site analog: A molecular dynamics simulation. J. Am. Chem. Soc. 115:7439-7444.