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Researchers are studying cadherin-23 (CDH23) and protocadherin-15 (PCDH15), two large proteins involved in hearing loss and balance disorders, using supercomputing resources allocated through XSEDE.

In PNAS in October 2020, they present multiple structures, models, and supercomputer simulations that depict the lower end of the tip link. Their work includes the complete PCDH15 ectodomain, which opens cochlear and vestibular channels to initiate signal transduction.

The researchers relied upon the XSEDE-allocated Stampede2 system at TACC and the Bridges system at PSC to start to understand the dynamics of the tip-link proteins.

They are looking forward to scaling up their simulations to the Frontera supercomputer at TACC.


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