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Study found that genes could be activated in human stem cells that initiate biomineralization, a key step in bone formation.

Scientists engineered spider web silk combined with silica to activate cell membrane protein receptor integrin.

XSEDE resources used include systems Stampede1 at the Texas Advanced Computing Center and Comet at the San Diego Supercomputer Center.

Research will help scientists model intracellular pathways that govern bone formation and efforts to cure diseases such as osteoporosis and calcific aortic valve disease.


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