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Story Highlights

Mechanism found for how HIV-1 virus imports nucleotides into its core that fuel DNA synthesis, a key step in its replication.

First example found where a virus recruits small molecules from a host cell into its core to conduct a process beneficial for its life cycle.

Supercomputer molecular dynamics simulations helped test translocation and free energy calculations.

Research supported by the NSF-funded XSEDE through TACC Stampede2 and PSC Bridges.

HIV-1 capsid research provides potential for new drug targets for therapeutic development such as improved anti-retroviral drugs.


Faith Singer

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