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Defects in DNA replication and repair processes contribute to the onset, progression, and prognosis of cancer.

Albino Bacolla studies cancer as a research investigator at the MD Anderson Cancer Center. His research focuses on genome instability and uses a computational approach to uncover mechanisms underlying cancer.

Specifically, Bacolla uses the XSEDE-allocated Stampede2 supercomputer at TACC to parallelize and run code on many processors to get the research done in a few days instead of months.

The paper is called "Cancer mutational burden is shaped by G4 DNA, replication stress and mitochondrial dysfunction'. It appeared in Progress in Biophysics and Molecular Biology, October 2019.


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